Rejuran in Singapore: The Ultimate Guide to Skin Healing & Rejuvenation

• 17 February 2026
• Dr. Sankeerth Reddy

Last updated on July 28, 2026

In the quest for a truly radiant, ‘glass skin’ complexion, it’s easy to feel overwhelmed by the sheer number of aesthetic treatments available in Singapore. You may have heard the buzz surrounding a unique treatment known as Rejuran, but with that comes a wave of questions. Is it a filler? What does ‘salmon DNA’ actually do for the skin? And is it the right choice for you compared to other popular options like Profhilo or Skinboosters? We understand that seeking clarity is the first step towards feeling confident in your skincare journey.

This guide is crafted to provide that clarity. Here, we will demystify the science behind Rejuran, exploring how its polynucleotides work to fundamentally repair and rejuvenate your skin from within. We will address your most pressing concerns-from the treatment process to its suitability for improving fine lines, pores, and overall texture. Our goal is to empower you with trusted, comprehensive information, helping you make an informed decision that honours your unique beauty and aligns with your long-term skin health goals. Discover if this celebrated ‘skin healer’ is the key to unlocking your most naturally luminous skin.

What is Rejuran? Demystifying the ‘Skin Healer’ Treatment

In the landscape of advanced aesthetic treatments, Rejuran stands apart not as a temporary fix, but as a fundamental solution for skin rejuvenation. Unlike traditional dermal fillers that add volume or skinboosters that primarily hydrate, Rejuran is a bio-regenerative treatment. Its core mission is to heal and repair damaged skin cells from within, fostering a healthier, more resilient skin structure for sustainable, long-term radiance.

The treatment harnesses the remarkable power of Polynucleotides (PN), a unique ingredient derived and purified from salmon DNA. You might wonder, why salmon? The reason lies in its exceptional biocompatibility. Salmon DNA shares a remarkable similarity with human DNA, making it safe, effective, and readily accepted by our bodies to initiate a profound cellular repair process. This approach honours your unique biology, working with your skin to restore its youthful vitality naturally.

The Science of Polynucleotides (PN): How It Works

At a cellular level, Polynucleotides are true architects of skin repair. When introduced into the dermis, these molecules act as powerful signalling agents. They work by stimulating fibroblasts-the skin’s foundational cells-to ramp up the production of new collagen and elastin. This process rebuilds the skin’s scaffold, improving elasticity and fine lines. Furthermore, PN creates an optimal environment for regeneration by improving blood flow and reducing inflammation. Its key actions include:

• Bio-stimulation: Activating fibroblasts to produce essential structural proteins.
• Anti-inflammatory Effects: Calming skin sensitivity and reducing redness, making it beneficial for conditions like rosacea or acne scars.
• DNA Repair: Providing the building blocks necessary for cells to repair damage caused by UV radiation and ageing.

Rejuran Healer (Injectable) vs. Rejuran Cosmetics (Topical)

It is important to distinguish between the clinical treatment and the take-home products. The Rejuran Healer is a minimally invasive injectable treatment performed by a qualified doctor. This method delivers the potent Polydeoxyribonucleotide (PDRN) directly into the dermis, where cellular repair is most needed. In contrast, Rejuran Cosmetics are topical skincare products designed to support and prolong the results of the in-clinic treatment or for daily use to maintain skin health.

Is Rejuran a Filler or a Skinbooster?

Rejuran defies simple categorisation. It is not a hyaluronic acid (HA) filler, as it does not add artificial volume or physically lift the skin. While it improves hydration, its primary function goes far beyond that of a typical skinbooster. Instead of just replenishing moisture, it actively repairs the skin’s underlying structure. For this reason, it is most accurately described as a ‘skin healer’ or a ‘bio-stimulator’-a treatment that empowers your skin to regenerate and heal itself for truly natural and enduring results.

The Key Benefits: What Can Rejuran Do for Your Skin?

Rejuran is more than a temporary aesthetic enhancement; it is a fundamental skin repair treatment designed to foster genuine, long-term rejuvenation. By working at a cellular level to regenerate tissue, it delivers tangible and sustainable improvements to your skin’s health and appearance. After completing a recommended course of treatments, patients can expect a range of profound benefits, including:

• Improved skin elasticity and firmness
• Refined skin texture and deep hydration
• A softening of fine lines and wrinkles
• Noticeable repair of difficult conditions like atrophic acne scars

Its remarkable versatility allows for targeted rejuvenation not just on the face, but also on the delicate skin of the neck, décolletage, and even the back of the hands.

Improving Skin Texture and Elasticity

The polynucleotides (PDRN) at the core of Rejuran treatment act as biological activators, signalling your skin’s own fibroblasts to rebuild the extracellular matrix. This process, which is supported by extensive research into the Pharmacological Activity and Clinical Use of PDRN, results in skin that is visibly firmer, denser, and more resilient. Patients often notice a significant reduction in fine, crepey lines and an overall improvement in skin quality, giving it a stronger, healthier foundation.

Minimising Pores and Normalising Skin

Beyond structural repair, this treatment helps restore vital balance to your skin’s ecosystem. It aids in regulating sebum production while simultaneously repairing the skin’s protective barrier. This dual action is beneficial for both oily and dry skin types, leading to a more normalised complexion. As the skin becomes healthier and oil production is controlled, the appearance of enlarged pores is visibly minimised, contributing to a smoother, more refined canvas.

Achieving the ‘Glass Skin’ Effect

The cumulative effects of cellular repair, deep hydration, and improved texture culminate in the coveted ‘glass skin’ effect. By healing the skin from within, this treatment enhances its natural ability to reflect light, resulting in a radiant, translucent complexion. Skin tone appears more even, and your face gains a subtle, healthy glow that looks entirely natural. It is the ultimate expression of luminous vitality. Begin your journey to radiant skin with a consultation.

The Rejuran Treatment Journey: From Consultation to Results

Embarking on any aesthetic treatment is a significant decision. To ensure your complete confidence and comfort, we believe in a transparent, meticulous, and doctor-led process. Understanding the journey from your initial discussion to seeing your final, radiant results is paramount. Here is a step-by-step guide to what you can expect with your Rejuran treatment plan.

Step 1: The Personalised Consultation

Your path to skin rejuvenation begins with a comprehensive consultation. This is not merely a procedural briefing; it is a deep dive into your unique skin concerns, medical history, and aesthetic aspirations. An experienced doctor will meticulously assess your skin’s condition to determine if Rejuran is the optimal solution for you. For instance, while hyaluronic acid fillers are excellent for adding volume, polynucleotides are superior for cellular repair and improving skin texture. Evidence from a clinical trial comparing polynucleotide and hyaluronic acid fillers supports its efficacy in skin regeneration, allowing us to create a holistic, evidence-based treatment plan tailored to you.

Effectively communicating your goals and understanding the expert’s perspective are key parts of any consultation. Developing strong interpersonal skills can empower you in these conversations and many other areas of life. For those looking to enhance their professional impact, you can explore Effective Negotiation and Influence with the Enneagram (WSQ).

Step 2: The Procedure Itself

On the day of your treatment, your comfort is our priority. The procedure begins with the application of a topical numbing cream to the target area, ensuring a virtually painless experience. Once your skin is sufficiently numbed, the doctor will administer the treatment using a series of precise micro-injections across the skin. This technique ensures the polynucleotides are delivered evenly to the dermal layer where they can work most effectively. The injection process itself is swift, typically completed in just 15 to 20 minutes.

Step 3: Aftercare and Downtime

Immediately following the procedure, you will notice small, raised bumps or papules at the injection sites, often described as resembling tiny bee stings. This is a completely normal and expected outcome, indicating the product has been placed correctly. These bumps typically subside entirely within 24 to 48 hours. To support optimal healing, we advise the following:

• Avoid applying makeup for at least 24 hours.
• Refrain from strenuous exercise, swimming, or saunas for 1-2 days.
• Be diligent with sun protection to protect the healing skin.

Step 4: Timeline for Results

Rejuran works by stimulating your skin’s natural regenerative capabilities, so results appear gradually and look entirely natural. The standard protocol involves an initial course of 3 to 4 sessions, spaced approximately 3 to 4 weeks apart. While some patients notice improved hydration and texture after the first session, visible improvements in fine lines, skin elasticity, and overall radiance are most often seen after the second treatment. The full, revitalising effects become most apparent a few weeks after completing the entire course, delivering sustainable and long-lasting skin quality improvement.

Rejuran vs. Other Popular Treatments: Making the Right Choice

Navigating the world of advanced aesthetic treatments can feel complex. While Profhilo is a leading contender, understanding how Rejuran compares to other popular options like Skinboosters and dermal fillers is crucial for developing a truly personalised rejuvenation strategy. The ideal choice always depends on your specific skin concerns and aesthetic goals.

To simplify this, here is a quick overview of how these leading treatments differ:

Rejuran vs. Skinboosters

While both treatments aim to improve skin quality, their mechanisms are distinct. Skinboosters utilise micro-droplets of Hyaluronic Acid to provide an immediate surge of surface-level hydration, resulting in a radiant, dewy complexion. Rejuran, however, works at a cellular level. Its Polynucleotides actively repair skin damage and stimulate collagen, building healthier, more resilient skin from within for more sustainable, long-term structural improvement.

Rejuran vs. Dermal Fillers

This comparison is about function, not competition. Dermal fillers are specifically designed to restore lost volume, lift sagging tissues, and sculpt facial contours. They physically add structure where it has diminished over time. In contrast, Rejuran enhances the quality and health of the skin itself-improving texture, elasticity, and thickness-without altering your fundamental facial shape. They are often used together as powerful partners for a complete anti-aging result.

Ultimately, the most sophisticated outcomes often arise from a synergistic approach. Combining a filler to restore mid-face volume with Rejuran to refine the overlying skin texture can create a comprehensive and beautifully natural-looking rejuvenation. A meticulous assessment is key to designing a plan that honours your unique identity. To discover the ideal treatment combination for your skin, we invite you to schedule a personal consultation.

Is Rejuran Right for You? Candidacy, Safety, and Cost in Singapore

Deciding on the right aesthetic treatment is a significant and personal journey. To help you make an informed choice, this section offers a practical guide to the key considerations for Rejuran in Singapore. We will explore who makes an ideal candidate, the treatment’s safety profile, and the expected costs, empowering you to pursue your skin health goals with complete confidence.

The Ideal Candidate for Rejuran

Rejuran is a versatile skin healer designed to fundamentally improve skin health from within. It is particularly effective for individuals seeking to address concerns such as:

• Dull, tired-looking skin lacking radiance
• Poor or uneven skin texture
• Fine lines and early signs of ageing
• Enlarged pores
• Depressed acne scars

Unlike dermal fillers, Rejuran does not add artificial volume. Instead, it focuses on repairing and rejuvenating your skin at a cellular level, making it an excellent choice for those who desire natural-looking revitalisation. It is also highly suitable for younger patients as a preventative treatment to maintain skin vitality and proactively manage the ageing process.

Safety, Approval, and Potential Side Effects

Your safety and well-being are paramount. We are pleased to confirm that Rejuran is approved for use by Singapore’s Health Sciences Authority (HSA), ensuring it meets rigorous standards for quality and safety. As with any injectable treatment, there are potential side effects, which are typically mild and transient. Most commonly, patients may experience small, temporary bumps, redness, or mild bruising at the injection points. These effects are a normal response and typically resolve within 24 to 48 hours. Entrusting your care to an experienced medical professional is the best way to ensure a safe procedure and minimise any potential discomfort.

Expected Cost of Rejuran in Singapore

In Singapore, the cost for a session of Rejuran generally ranges from S$600 to S$900. The final price depends on several factors, including the specific clinic, the experience of the doctor, and the extent of the area being treated. For optimal and sustainable results, an initial course of 3-4 sessions, spaced approximately four weeks apart, is typically recommended to allow the treatment to progressively repair skin and stimulate collagen. To receive an accurate assessment tailored to your unique skin condition, we invite you to request a personalised treatment plan and quote from our clinic.

Embrace Your Skin’s Potential with Expert Guidance

Throughout this guide, we’ve seen how Rejuran transcends typical aesthetic treatments, acting as a fundamental ‘skin healer’ to repair and regenerate from within. It offers a sophisticated path to smoother texture, improved elasticity, and a truly radiant complexion. The most crucial takeaway, however, is that optimal results are born from a strategy that is as unique as your skin.

Your journey should be guided by expertise you can trust. With over 15 years of medical experience, Dr. Sankeerth Reddy specialises in creating personalised, doctor-led treatment plans. His philosophy centres on delivering natural, subtle enhancements that honour your unique beauty. To determine if a bespoke rejuran treatment is the right step for you, we invite you to begin a conversation grounded in professional, compassionate care.

Consult with Dr. Reddy to discover if Rejuran is the right choice for your skin. Your path to renewed confidence and vitality begins here.

Frequently Asked Questions About Rejuran

How painful is the Rejuran treatment?

Patient comfort is our utmost priority. Before the procedure, a topical numbing cream is applied to minimise sensation. During the treatment, you may feel a series of small, brief pricks, but most patients in our Singapore clinic find it very tolerable. Our meticulous injection technique is designed to ensure the experience is as comfortable as possible, allowing you to begin your journey to skin rejuvenation with minimal discomfort.

How long do the results of Rejuran last after completing the initial course?

After completing the initial recommended course of 3-4 sessions, the skin-rejuvenating effects of Rejuran typically last for 6 to 12 months. The polynucleotides work to repair your skin at a cellular level, promoting sustained collagen production. To maintain optimal skin health and prolong the radiant results, we generally recommend a single maintenance session every 6 months, ensuring a lasting, youthful vitality.

Are there any long-term side effects of using salmon DNA for skin treatments?

The Rejuran treatment utilises highly purified polynucleotides (PN) derived from salmon DNA, which are exceptionally biocompatible and safe for human use. Having undergone rigorous purification processes, there are no known significant long-term side effects. The PN is naturally metabolised by your body over time. In Singapore, it is an HSA-approved treatment, trusted for its excellent safety profile when administered by a qualified medical professional.

What is the difference between Rejuran Healer, Rejuran I (Eye), and Rejuran S (Scar)?

Each product in the Rejuran line is formulated for a specific purpose. Rejuran Healer is the most versatile, used for overall facial rejuvenation to improve skin texture and elasticity. Rejuran I (Eye) has a lower viscosity, making it ideal for the delicate skin around the eyes to soften fine lines. Rejuran S (Scar) is the most viscous formulation, specifically designed to repair and plump up depressed acne scars by providing a structural scaffold for collagen regeneration.

How soon will I see visible results after my first Rejuran session?

While some patients notice improved skin hydration and texture within a week, the true benefits of the Rejuran treatment unfold gradually as it works by stimulating your body’s natural repair processes. More significant improvements in skin elasticity, pore size, and fine lines typically emerge around 3 to 4 weeks after the first session. The full, radiant effect is best appreciated after completing the recommended initial course of treatments.

Can I wear makeup or go to the gym after a Rejuran injection?

To ensure optimal healing and prevent any risk of infection at the injection points, we advise avoiding makeup for at least 24 hours post-treatment. We also recommend refraining from strenuous exercise, saunas, and excessive alcohol consumption for 24 to 48 hours. This helps to minimise potential swelling or bruising, allowing your skin to recover smoothly and effectively for the best possible outcome from your treatment.

Is Rejuran suitable for sensitive or acne-prone skin?

Yes, Rejuran is often an excellent choice for both sensitive and acne-prone skin types. Its core ingredient, polynucleotide (PN), possesses powerful anti-inflammatory and regenerative properties that help to repair a compromised skin barrier and soothe irritation. It can also help regulate oil production and improve the appearance of acne scars, making it a holistic treatment for achieving clearer, more resilient, and balanced skin. A consultation is key to confirming suitability.